First launch of the Antares launch vehicle, combining surplus rocket engines from the Soviet N1 moon rocket program with US-built components. The mass simulator carried instrumentation to measure the launch vehicle environment in preparation for future launches of the Cygnus spacecraft designed to carry cargo to the International Space Station. It also released four cubesats into independent orbits.

First Orbital Sciences Cygnus ISS resupply spacecraft. Named SS G. David Low after the late astronaut, son of the former NASA administrator, and Orbital employee. The Cygnus consisted of a pressurized cargo module (PCM) built by Thales Alenia in Torino, and a service module (SM) built by Orbital/Dulles. The craft carried 700 kg of cargo. Intiial orbit was 261 km x 277 km x 51.6 deg; at 20:07 GMT this was raised to 274 km x 384 km. On 22 September the first attempt at rendezvous with the ISS was cancelled due to a software problem in the GPS navigation system; Cygnus passed ISS at a distance of 4 km at 08:45 GMT. On 29 September Cygnus completed its rendezvous with ISS, reaching a 250 m hold point at 09:08 GMT. The SSRMS arm captured Cygnus at 11:00 GMT, and after berthing to the Harmony module of the ISS he astronauts began unloading the ship's cargo. Cygnus unberthed from Harmony at 10:04 GMT on 22 October and was released into a 415 x 419 km orbit by the SSRMS at 11:31 GMT. On 23 October Cygnus conducted its retrofire burn at 17:41 GMT, and burnt up at 18:16 GMT over the South Pacific.

Delivered 1,261 kg of cargo to the ISS. The Cygnus cargo ship SS C. Gordon Fullerton entered an initial 221 x 259 km x 51.6 deg orbit to begin its rendezvous sequence with ISS. Arrived at 250 metres from ISS at 10:01 GMT January 12; moved in to the 10 m capture position; then captured by the Canadarm-2 at 11:08 GMT and berthed on the Harmony module's nadir port at 13:05 GMT. It contained 1465 kg of cargo for ISS, including two bags with a total mas of 152 kg containing a set of 28 Dove 3U Earth-observing cubesats (about 5 kg each) for Planet Labs and five 1U/2U cubesats. Unberthed from the Harmony module and released by the robot arm at 11:42 GMT 18 February. After two orbital maneuvers Cygnus underwent destructive reentry over the Pacific with loss of signal at 18:23 GMT February 19. First launch of Orbital's Antares 120 variant, with a more powerful ATK Castor 30B second stage replacing the Castor 30 used on earlier flights.

Delivered 1,494 kg of cargo to the ISS. After rendezvous with the ISS the station's SSRMS arm grappled it at 10:36 GMT on July 16 and berthed it to the Harmony module at 12:53 GMT. Unberthed at 09:14 GMT on August 15 and released by Canadarm-2 at 10:40 GMT. Deorbited and reentered at 13:15 GMT on 17 August over the South Pacific.

The Orbital Cygnus Orb-3 cargo ship; destroyed during launch. As well as ISS cargo, the Orb-3 mission was carrying 26 PlanetLabs Flock-1d 3U cubesats, the JPL/U-Texas RACE 3U cubesat, the Arkyd-3 3U cubesat from Planetary Resources, and also the GOMX-2 ship tracking 2U cubesat from GOMX of Aalborg, Denmark.

Orbital ATK Cygnus cargo ship, the SS Alan Poindexter, was launched on mission OA-5. The launch was the first flight of the Antares 230 rocket, featuring a first stage with two Energomash RD-181 engines replacing the Kuznetsov/Aerojet AJ-26 engines used on earlier Antares missions (which were implicated in the Oct 2014 Antares 130 failure), and a second stage with the Castor 30XL solid motor. The Castor 30XL was on the previous Antares launch but didn't get a chance to fire because of the first stage failure, so this was its first real test. In the event the rocket performed above specification and the mission reached a higher-than-planned 209 x 351 km orbit. OA-5 reached the ISS on Oct 23; it was grappled by the SSRMS at 1128 UTC and berthed to the nadir port of the Unity module at 1453 UTC. Cygnus OA-5 carried 2345 kg of pressurized cargo, and the external Nanoracks deployer with four Spire Global Lemur-2 cubesats.Cygnus cargo vehicle SS Alan Poindexter (OA-5) was unberthed from the Unity module at about 1125 UTC Nov 21 and released into space at 1322 UTC. It raised its orbit on Nov 25 to 495 x 504 km and released two pairs of Spire Global cubesats in the Lemur-2 series. Cygnus was deorbited on Nov 27, reentering over the S Pacific at 2336 UTC.

See EQUiSat↑. 1U cubesat by Brown University. Mission: Open-source satellite to encourage involvement of students and amateurs in aerospace design. Status as of 2019: Active. Accepted to NASA's CubeSat Launch Initiative in 2014. .